Overview
MailerSend and Mandrill are both transactional email services with different setups. MailerSend is standalone. Mandrill requires a Mailchimp account.
Independence
MailerSend is standalone—sign up and use. Mandrill requires a Mailchimp account. If you're not using Mailchimp, MailerSend is simpler.
Mailchimp Integration
For existing Mailchimp users, Mandrill is the natural choice. Everything in one ecosystem with native marketing integration.
Email Verification
MailerSend includes email verification. Mandrill doesn't. For validating addresses, MailerSend is more complete.
For SaaS Companies
Neither has native Stripe integration. Sequenzy offers Stripe integration for subscription businesses with modern unified platform.
Making the Choice
Choose MailerSend for standalone transactional with email verification. Choose Mandrill if you're already using Mailchimp and want unified ecosystem.